Anthony Di Pasqua

Publications

• Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B., Dubowy, R. L. and Dabrowiak, J. C. (2006) Activation of carboplatin by carbonate. Chem. Res. Toxicol. 19, 139-149.
• Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B., Dubowy, R. L. and Dabrowiak, J. C. (2007) Role of carbonate in the cytotoxicity of carboplatin. Chem. Res. Toxicol. 20, 896-904.
• Di Pasqua, A. J., Goodisman, J., Kerwood, D. J., Toms, B. B. and Dabrowiak, J. C. (2007) Modification of carboplatin by Jurkat cells. J. Inorg. Biochem. 101, 1438-1441.
• Di Pasqua, A. J., Sharma, K. K., Shi, Y.-L., Toms, B. B., Ouellette, W., Dabrowiak, J. C. and Asefa, T. (2008) Cytotoxicity of mesoporous silica nanomaterials. J. Inorg. Biochem. 102, 1416-1423.
• Sorokanich, R. S., Di Pasqua, A. J., Geier, M. and Dabrowiak, J. C. (2008) Influence of carbonate on the binding of carboplatin to DNA. Chem. Biodivers. 5, 1540-1544.
• Di Pasqua, A. J., Centerwall, C. R., Kerwood, D. J. and Dabrowiak, J. C. (2009) Formation of carbonato and hydroxo complexes in the reaction of platinum anticancer drugs with carbonate. Inorg. Chem. 48, 1192-1197.
• Di Pasqua, A. J., Mishler II, R., Shi Y.-L., Dabrowiak, J. C. and Asefa, T. (2009) Preparation of antibody-conjugated gold nanoparticles. Mater. Lett. 63, 1876-1879.
• Di Pasqua, A. J., Wallner, S., Kerwood, D. J. and Dabrowiak, J. C. (2009) Adsorption of the Pt2+ anticancer drug carboplatin by mesoporous silica. Chem. Biodivers. 6, 1343-1349.
• Di Pasqua, A. J., Hong, C., Wu, M. Y, McCracken, E., Wang, X., Mi, L. and Chung, F.-L. (2010) Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates. Chem. Res. Toxicol. 23, 1307-1309.
• Wang, X.*, Di Pasqua, A. J.*, et al. (2011) Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. J. Med. Chem. 54, 809-816. *Co-first authors
• Di Pasqua, A. J., Kerwood, D. J., Shi, Y., Goodisman, J. and Dabrowiak, J. C. (2011) Stability of carboplatin and oxaliplatin in their infusion solutions is due to self-association. Dalton Trans. 40, 4821-4825.
• Mi, L., Di Pasqua, A. J. and Chung, F. L. (2011) Proteins as potential targets of cancer prevention by isothiocyanates. Carcinogenesis 32, 1405-1413.
• Di Pasqua, A. J.*, Huckle, J. E.*, Kim, J.-K., Chung, Y, Jay, M. and Lu, X. (2012) Preparation of neutron activatable holmium-nanoparticles for the treatment of ovarian cancer metastases. Small 8, 997-1000.*Co-first authors
• Di Pasqua, A. J., Goodisman, J. and Dabrowiak, J. C. (2012) Understanding how the platinum anticancer drug carboplatin works: From the bottle to the cell. Inorg. Chim. Acta 389, 29-35.
• Di Pasqua, A. J., Miller, M. L., Lu, X., Peng, L. and Jay, M. (2012) Tumor accumulation of neutron-activatable holmium-containing mesoporous silica nanoparticles in an orthotopic non-small cell lung cancer mouse model. Inorg. Chim. Acta 393, 334-336.
• Di Pasqua, A. J., Yuan, H., Chung, Y., Kim, J.-K., Huckle, J. E., Li, C., Sadgrove, M., Tran, T. H., Jay, M. and Lu, X. (2013) Neutron-activatable holmium-containing mesoporous silica nanoparticles as a potential radionuclide therapeutic agent for ovarian cancer. J. Nucl. Med. 54, 111-116.
• Yang, Y.-T., Di Pasqua, A. J., He, W., Tsai, T., Sueda, K, Zhang, Y. and Jay M. (2013) Preparation of alginate beads containing a prodrug of diethylenetriaminepentaacetic acid. Carbohyd. Polym. 92, 1915-1920.
• Sueda, K., Sadgrove, M., Jay, M.* and Di Pasqua, A. J.* (2013) Species-dependent effective concentration of DTPA in plasma for chelation of 241Am. Health Phys. 105, 208-214. *Co-corresponding authors
• Yang, Y.-T., Di Pasqua, A. J., Zhang, Y., Sueda, K. and Jay, M. (2014) Solid dispersions of the penta-ethyl prodrug of diethylenetriaminepentaacetic acid (DTPA) for radionuclide decorporation by oral administration. Pharm. Dev. Technol. 19, 806-812.
• Yang, Y.-T., Shi, Y., Jay, M. and Di Pasqua, A. J.* (2014) Enhanced toxicity of cisplatin with chemosensitizer phenethyl isothiocyanate toward non-small cell lung cancer cells when delivered in liposomal nanoparticles. Chem. Res. Toxicol. 27, 946-948. *Corresponding author
• Shi, Y., Koneru, B., Redfearn, W., Miller, M. L., Myers, L. and Di Pasqua, A. J.* (2014) Platinum(IV) cisplatin derivative trans, cis, cis-bis(heptanoato)amine(cyclohexylamine)dichloridoplatinum(IV) has an enhanced therapeutic index compared to cisplatin for the treatment of non-small cell lung cancer. Inorg. Chim. Acta 423B, 215-219. *Corresponding author
• Munaweera, I., Koneru, B., Shi, Y., Di Pasqua, A. J.* and Balkus, Jr., K. J.* (2014) Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy. APL Materials 2, 113315.1-113315.13. *Co-corresponding authors
• Munaweera, I., Levesque-Bishop, D., Shi, Y., Di Pasqua, A. J.* and Balkus, Jr., K. J.* (2014) Novel radiotherapeutic bandage based on electrospun polyacrylonitrile containing holmium-166 iron garnet nanoparticles for the treatment of skin cancer. ACS Appl. Mater. Interfaces6, 22250-22256. *Co-corresponding authors
• Munaweera, I., Shi, Y., Koneru, B., Saez, R., Aliev, A., Di Pasqua, A. J.* and Balkus, Jr., K. J.* (2015) Chemoradiotherapeutic magnetic nanoparticles for targeted treatment of non-small cell lung cancer. Mol. Pharm. 12, 3588-3596. *Co-corresponding authors
• Munaweera, I., Shi, Y., Koneru, B., Patel, A., Dang, M. H., Di Pasqua, A. J.* and Balkus, Jr., K. J.* (2015) Nitric oxide- and cisplatin-releasing silica nanoparticles for use against non-small cell lung cancer. J. Inorg. Biochem. 153, 23-31. *Co-corresponding authors
• Koneru, B., Shi, Y., Chavala, S., Miller, M. L., Holbert, B., Conson, M., Ni, A. and Di Pasqua, A. J.* (2015) Preparation of tetracycline-containing MCM-41 mesoporous silica nanoparticles for controlled drug release. Molecules 20, 19690-19698. *Corresponding author
• Shi, Y., Miller, M. L. and Di Pasqua, A. J.* (2016) Biocompatibility of mesoporous silica nanoparticles? Comments Inorg. Chem. 36, 61-80. *Corresponding author
• Koneru, B., Shi, Y., Munaweera, I., Kadara, H., Yuan, H., Di Pasqua, A. J.* and Balkus, Jr. K. J.* (2016) Radiotherapeutic bandage for the treatment of squamous cell carcinoma of the skin. Nucl. Med. Biol. 43, 333-338. *Co-corresponding authors
• Lin, V. J., Zolekar, A., Shi, Y., Koneru, B., Dimitrijevich, S., Di Pasqua, A. J. and Wang, Y.-C. (2017) Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells. Sci. Rep. 7, 5005.
• Shi, Y., Johnsen, A. and Di Pasqua, A. J.* (2017) Holmium for use in cancer therapy. Comments Inorg. Chem.37, 281-300. *Corresponding author
• Spencer, S. A., Riley, A. C., Matthew, A. and Di Pasqua, A. J. (2019) Brigatinib: Novel ALK inhibitor for non-small-cell lung cancer. Ann. Pharmacother. 53, 621-626.
• Sun, M., Shi, Y., Dang, U. J. and Di Pasqua, A. J.* (2019) Phenethyl isothiocyanate and cisplatin co-encapsulated in a liposomal nanoparticle for treatment of non-small cell lung cancer. Molecules 24, 801-813. *Corresponding author
• Osipitan, O. O., Shi, Y. and Di Pasqua, A. J.* (2021) Phenethyl isothiocyanate-containing carbomer gel for use against squamous cell carcinomas. Pharmaceutics 13, 106-117.  *Corresponding author
• Sun, M., Yuan, Y., Lu, F. and Di Pasqua, A. J.* (2021) Physicochemical factors that influence the biocompatibility of cationic liposomes and their ability to deliver DNA to the nuclei of ovarian cancer SK-OV-3 cells. Materials 14, 416-429. *Corresponding author
• Dlott, A., Di Pasqua, A. J.* and Spencer, S. A.* (2021) Tirbanibulin: Topical treatment for actinic keratosis. Clin. Drug Investig. 41, 51-755. *Co-corresponding authors
• Gaurkhede, S. G., Osipitan, O. O., Dromgoole, G., Spencer, S. A., Di Pasqua, A. J.* and Deng, J.* (2021) 3D Printing and dissolution testing of novel capsule shells for use in delivering acetaminophen. J. Pharm. Sci. 110, 3829-3837. *Co-corresponding authors
• Sun, M., Dang, U. J., Yuan, Y., Psaras, A. M., Osipitan, O., Brooks, T. A., Lu, F. and Di Pasqua, A. J.* (2022) Optimization of DOTAP/chol cationic lipid nanoparticles for mRNA, pDNA, and oligonucleotide delivery. AAPS PharmSciTech 23, 135. *Corresponding author
• Sun, M., Osipitan, O. O., Sulicz, E. K. and Di Pasqua, A. J. (2022) Preparation and optimization of an Ultraflexible liposomal gel for lidocaine transdermal delivery. Materials 15, 4895. *Corresponding author
• Osipitan, O. O., Sun, M., Gordish-Dressman, H., Wendt, III, R., Wight-Carter, M, Balkus, Jr., K. J. and Di Pasqua, A. J. (2022) Laminated holmium-166-containing electrospun bandages for use against skin cancer. Nucl. Med. Biol. 114-115, 78-58. *Co-corresponding authors
• Gaurkhede, S. G., Wang, C., Di Pasqua, A. J., Zhou, Y. and Deng, J. 3D Printing novel enteric capsule shells for personalized drug delivery. Manufacturing Letters 41, 891-897.
• Dlott, A. H., Spencer, S. A. and Di Pasqua, A. J.* Calcipotriol and 5-fluorouracil combination therapy for the treatment of actinic keratosis in the clinic: A review article. Clin. Drug Investig. 44, 733-737. *Corresponding author

Book Chapters

• Akpan, N., Carson, R. E., Di Pasqua, A. J., Fasullo, M. T., Gobalakrishnan, S., Pryma, D. A., van Dam, M., Waltar, A. and Zhao, W. Identify improvements in technology and other approaches that will ensure the future development and supply of radionuclides and radiopharmaceuticals for diagnostic imaging and therapy (IDR Team Summary – Group 1C). In: The Future of Advance Nuclear Technologies: Interdisciplinary Research Team Summaries. The National Academies Press, Washington, D.C., 2014, pp. 20-26.
• Sun, M. and Di Pasqua, A. J.* A method for liposome co-encapsulation of phenethyl isothiocyanate and cisplatin and determining its toxicity against lung and lung cancer cells. In: Methods Mol. Biol. 2279, 241-253. Springer Publishing, 2021. *Corresponding author

Issued Patents

• Di Pasqua, A. J., Lu, X. and Jay, M. Stable activatable particles as radiotherapeutic agents for the treatment of disease. U.S. Patent 9327038, issued on May 3, 2016.
• Di Pasqua, A. J., Balkus, Jr., K. J., Munaweera, I., Shi, Y. Iron garnet nanoparticles for cancer radiotherapy and chemotherapy. U.S. Patent 9808543, issued on November 7, 2017.
• Di Pasqua, A. J., Balkus, Jr., K. J., Munaweera, I., Shi, Y. Iron garnet nanoparticles for cancer radiotherapy and chemotherapy. U.S. Patent 10195297, issued on February 5, 2019.

Awards & Honors

• 2003 Graduated Summa Cum Laude from Utica College of Syracuse University
• 2006 Given the Gemini Industries Graduate Student Award from the International Precious Metals Institute
• 2009 Awarded the Syracuse University College of Arts and Sciences Doctoral Prize for his dissertation, Carboplatin: Exploring mechanism of action and improved drug delivery
• 2013 One of approximately one hundred researchers invited to attend the 11th Annual National Academies of Sciences Keck Futures Initiative (NAKFI) Conference, The Future of Advanced Nuclear Technologies: Building a Healthier and Safer Planet
• 2015 Research highlighted in an “EurekAlert!” from the American Association for the Advancement of Science (AAAS)
• 2024 Received the 2024 High Impact Paper Award from the American Association of Pharmaceutical Scientists (AAPS) PharmSciTech for his corresponding author paper, Optimization of DOTAP/chol cationic lipid nanoparticles for mRNA, pDNA, and oligonucleotide delivery