Carolyn Friel, RPh, PhD
Professor of Medicinal Chemistry
About
Education
- BSP, University of Rhode Island
- PhD, Medicinal Chemistry, Northeastern University
Research Interests
- Medicinal Chemistry
Featured Affiliations
American Association of Colleges of Pharmacy
AACP Section of Teachers of Chemistry -
Programming Committee and Mentoring Committee
Education
- BSP, University of Rhode Island
- PhD, Medicinal Chemistry, Northeastern University
Research Interests
- Medicinal Chemistry
Publications
- Smith C, Friel CJ, Development and use of augmented reality models to teach medicinal chemistry. Curr. Pharm. Teach. Learn. 2021, 13, 1010–1017. [Google Scholar] [CrossRef]
- Yu JA, Friel C and Smith C, Lead optimization of aminopyrazole analogues for antileishmanial activity. American Chemical Society National Meeting, August 19, 2020. (Virtual)
- Iacoviello A, Kim JK, Lee J, Friel C, and Smith C. In silico optimization of amino-pyrazole ureas as anti-leishmanial agents. AAPS PharmSci360 National Meeting, October 24, 2020. (Virtual)
- Rathod S, LaPointe T, Gardella A, Lee L, Strauser G, Urbstonaitis R, Carr V, Friel C, and Mistry A. Comparison of pharmacovigilance postdoctoral PharmD industry fellowships across the United States #: F-242 ASHP Midyear Clinical Meeting, December 8, 2020 (Virtual)
- Lashkenari N, Yu JA, Iacoviello A, Kim JH, Lee J, Espinosa C, Friel CJ and Smith C. Anti-leishmaniasis compound design and optimization for the treatment of visceral leishmaniasis. 2020 ASHP Midyear Clinical Meeting, December 9, 2020. (Virtual)
- Reid K, Zaheen Z, Chartier S, Friel CJ and Smith C. Anti-leishmaniasis compound design and optimization for the treatment of visceral leishmaniasis SP-57, 2020 ASHP Midyear Clinical Meeting, December 9, 2020 (Virtual)
- Onyiuke E, Nguyen I, Patel D, Friel CJ and Smith C In silico optimization of a lead compound in the search for a treatment of visceral leishmaniasis # SP-59 2020 ASHP Midyear Clinical Meeting, December 9, 2020 (Virtual)
- Onyiuke E, Nguyen I, Patel D, Reid K, Zaheen Z, Maccarone R, Friel C, Smith CC. In Silico optimization of a lead compound in the search for a treatment for visceral leishmaniasis. New England Science Symposium, Harvard University, April 24, 2021 (Virtual)
- Friel C.J. (2020) Chapter 7: General and Local Anesthetic Agents. In M. O. Faruk Khan and A. Philip (Eds.), Medicinal Chemistry for Pharmacy Students, Volume 2, Medicinal Chemistry of Drugs Affecting the Nervous System: (pp. 300-320) Bentham Science Publishers.
Awards and Honors
- Teacher of the Year, Department of Pharmaceutical Sciences 2006-2007
- APhA Teacher Appreciation Award Massachusetts College of Pharmacy 2002-2003 Class of 2004; 2006-2007 Class of 2008
- SGA P2 Professor of the Year Class of 2010
- SGA P2 Professor of the Year Class of 2010, Class of 2011
- Hanson RN, Friel CJ, Dilis R, Hughes A, and DeSombre ER. (2005) Synthesis and Evaluation of (17 a,20Z)-21-(4-Substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols as Ligands for the Estrogen Receptor-aHormone Binding Domain: Comparison with 20E-Isomers. J. Med. Chem; 48(13); 4300-4311.
- Mobley JA, L'Esperance JO, Wu M, Friel CJ, Hanson RN, and Ho SM. (2004) The novel estrogen 17 a-20Z-21-[(4-amino) phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro. Mol. Cancer Ther. 3: 587-596.
- Hanson RN, Lee CY, Friel CJ, Hughes A, and DeSombre ER. (2003) Evaluation of 17alpha-E-(trifluoromethylphenyl) vinyl estradiols as novel estrogen receptor ligands. Steroids 68:143-8.
- Hanson RN, Lee CY, Friel CJ, Dilis R, Hughes A, DeSombre ER. (2003) Synthesis and evaluation of 17 a20E-21-(4-substituted phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols as probes for the estrogen receptor hormone binding domain. Journal of Medicinal Chemistry 46(14):2865-2876.
- Sebag A, Friel CJ, Hanson RN, Forsyth D. (2000) Conformational Studies on (17 a,20Z)-21-(x-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17 ß-diols Using 1D and 2D NMR spectroscopy and GIAO Calculations of 13C Shieldings. Journal of Organic Chemistry 65(23): 7902-7912.
- Friel CJ. Ch. 22 Anesthetics In: Beale JM, Jr, Block JH, editors. Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. 12th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2011; p. 711-32.
- Friel CJ and Lu, M.. Ch. 24 Analgesic Agents In: Beale JM, Jr, Block JH, editors. Wilson and Gisvolds Textbook of Organic Medicinal and Pharmaceutical Chemistry. 12th ed. Philadelphia, PA: Wolters Kluwer Lippincott Williams and Wilkins; 2011; p. 776-818.
- Friel CJ, Eliadi C, Pesaturo KA (2010) Local Anesthetic Use in Perioperative Areas, Perioperative Nursing Clinics 5(2), 203-214.
More Affiliations
- NABP/FPGEE Committee Member
- Rho Chi National Honor Society
- Academic Standing Committee
- Faculty Council