Stephen Kerr, PhD
Professor of Medicinal Chemistry
School
School of Pharmacy
Department
School of Pharmacy
Office Location
704 Huntington
Boston
Office Phone Office Phone: 617.732.2093
About
Education
- PhD in Medicinal Chemistry, University at Buffalo (SUNY)
- BS (Pharmaceutical Technology), Department of Chemical Technology, Bombay University
- BS (Chemistry), St. Xavier's College, Bombay University
- Post-doctoral Fellow, Yale University School of Medicine
Research Interests
- Mechanistic enzymology of viral DNA polymerases
- Anti-viral and anti-cancer drug and pro-drug design
- Cellular toxicology of phenolic anti-oxidants in cell culture models
- Drug metabolism studies
Featured Affiliations
American Society for Pharmacology and Experimental Therapeutics (ASPET)
WebsiteAmerican Association of Colleges of Pharmacy
WebsiteSociety of Toxicology (SOT)
WebsiteAmerican Association of Pharmaceutical Scientists (AAPS)
WebsiteEducation
- PhD in Medicinal Chemistry, University at Buffalo (SUNY)
- BS (Pharmaceutical Technology), Department of Chemical Technology, Bombay University
- BS (Chemistry), St. Xavier's College, Bombay University
- Post-doctoral Fellow, Yale University School of Medicine
Research Interests
- Mechanistic enzymology of viral DNA polymerases
- Anti-viral and anti-cancer drug and pro-drug design
- Cellular toxicology of phenolic anti-oxidants in cell culture models
- Drug metabolism studies
Publications
- Marwa Alsulaimany, and Stephen G. Kerr (2018) "Study of the Chemo-sensitizing Effects of Thymoquinone, the Active Constituent of Negilla Sativa (Black Seed), to Nitrogen Mustards, Chlorambucil and Cyclophosphamide, in Human Melanoma Cell Lines" FASEB J, Volume 32, Issue 1_supplement 01 Apr 2018
- Raed Alghamdi, and Stephen G. Kerr (2018) "Cytoprotective Effect of two Flavanoids - Catechin and Epicatechin, Against Oxidative Stress Induced by Cumene Hydroperoxide, in MCF-7 Cells." FASEB J, Volume 32, Issue 1_supplement 01 Apr 2018
- Chuong M, Taglieri C, Kerr S. (2017) “To flavor or not to flavor extemporaneous omeprazole liquid.” Int. J. Pharm. Compd. 21 (Sept-Oct), 418-430.
- Nada Tawfeeq and Stephen Kerr (2016). "Synthesis and Studies of N, N-(Dimethylamino) Methylene Prodrugs of Gemcitabine, Ara-A and Ara-G." FASEB J, Volume 30, Issue 1_supplement 1 Apr 2016
- Babiarz JC, Melaragni F, Kerr S, Kuchimanchi P. (2015) “Confounding issues in cancer progress – the impact of investor requirements on senior management compensation and regulatory decisions: tivozanib and Aveo Pharmaceuticals.” Therapeutic Innovation and Regulatory Science 49 (3), 333-341.
- Silva MA, Chuong M, Kerr S, Cabrera A. (2013) “Stability of two long acting insulin formulations after 28 days” J Pharmacy Practice and Research, 43, 37-40.
- Kerr, S.G. (2012) “Drug Discovery Through Enzyme Inhibition” In Foye’s Principles of Medicinal Chemistry. Eds. T. Lemke and D.W. Williams. (7th. ed . Lippincott, Williams and Wilkins, Baltimore, USA)
- Chen M, Howe, D, LeDuc, B, Kerr, SG and Williams, DA. (2010) "Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol." Drug Metab. Dispos. 38: 368 - 375.
- R. Sarangarajan, G. Acquaah-Mensah, K. A. Hoey, S. Kerr (2009). Transition From Primary To Metastatic Melanoma Is Associated With Differential Expression Of Genes Regulating Intracellular Levels Of Glutathione (GSH). Melanoma and Pigment Cell Research, 22 (7),PP10-3, 317, 2009.
- G. Acquaah-Mensah, K. A. Hoey, S. Kerr and R. Sarangarajan.(2009) "Transcriptional regulatory relationships involving Glutathione S-Transferase (GST) and oxidative stress related gene products: targets influencing melanotoxicity of substituted phenols." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 935, March 2009.
- K. A. Hoey, S. Kerr and R. Sarangarajan (2009). "Expression/activity of Glutathione S-Transferase isoform (GST-?) is associated with increased sensitivity to 4-tertiary butylphenol (4-TBP) toxicity: implications for occupational vitiligo." The Toxicologist CD - An official Journal of the Society of Toxicology, Volume 102, Number S-1, PS 1054, March 2009.
- Sarangarajan, R., Friel, C and Kerr, S (2008) . "Characterization of the interaction between antioxidants and 4-TBP in the etiology of occupational vitiligo." Melanoma and Pigment Cell Research, 21 (7),PP10-3, 317, 2008.
- Kerr, S.G. (2007) "Drug Discovery Through Enzyme Inhibition" in Foye's Principles of Medicinal Chemistry. Eds. T. Lemke and D.W. Williams. (6th. ed . Lippincott, Williams and Wilkins, Baltimore, USA)
- Chen M, Howe, D, LeDuc, B, Kerr, SG and Williams, DA. (2007). "Identification and Characterization of Two Chloramphenicol Glucuronides from the in vitro Glucuronidation of Chloramphenicol in Human Liver Microsomes." Xenobiotica 37 (9): 954 -971.
- Kerr SG and Anderson KS. (1997) "Pre-Steady State Kinetic Characterization of Wild Type and 3'-Azido-3'-deoxythymidine (AZT) Resistant Immunodeficiency Virus Type 1 Reverse Transcriptase: Implication of RNA Directed DNA Polymerization in the Mechanism of AZT Resistance." Biochemistry 36, 14064 - 14070.
- Kerr SG and Anderson, KS. (1997) “RNA Dependent DNA Replication Fidelity of HIV-1 Reverse Transcriptase: Evidence of Discrimination Between DNA and RNA Substrates.” Biochemistry 36, 14056 – 14063.
- Kerr, S. G. and Kalman, T.I. (1994) “N4-(Dialkylamino)methylene Derivatives of 2’-deoxycytidine and Arabinosyl Cytosine: Physicochemical Studies for Potential Prodrug Applications.” J. Pharm. Sci. 83: 582 586.
- Kerr, S. G. and Kalman, T.I. (1992) "Highly Water Soluble Lipophilic Prodrugs of the Anti-HIV Nucleoside Analogue 2',3'-Dideoxycytidine (ddC) and it's 3'-Fluoro Derivative." J. Med. Chem. 35: 1996 - 2001.
Awards and Honors
- 2014 Faculty Scholarship Showcase Award (Integration)
- 2014 Phi Kappa Phi – Charter Member
- 2012 Distinguished Trustees Award for Teaching Excellence
- 2011 Pharmaceutical Sciences Teacher of the Year Award
- 2010 Scholarly Publication Award (Basic Sciences) - MCPHS
- 2010 One Year Faculty Service Award, MCPHS
- 2007 Long Term Faculty Service Award, MCPHS
- 2007 Phi Lambda Sigma (National Pharmacy Leadership Society) - Faculty Inductee
- 2004 Short Term Faculty Service Award, MCPHS
- 2003 Rho Chi (Academic Honor Society in Pharmacy) - Faculty Inductee
- 2002 Sigma Xi (Scientific Research Society) - Inductee
- 1999 Scholarly Publication Award (Basic Sciences) - MCPHS
- 1992 -1996 Post-doctoral Research Fellowship, Yale University School of Medicine
More Affiliations
- Sigma Xi - Scientific Research Society - Vice President (Delta Chapter)
- American Association for the Advancement of Science
- Rho Chi (Pharmacy Honor Society)
- Phi Lambda Sigma (Pharmacy Leadership Society)
- Phi Kappa Phi (Honor Society)