School
School of Arts and Sciences
Department
School of Arts and Sciences
About
Dr. Rollins is an adjunct faculty member at MCPHS, specializing in infectious diseases. He earned his PhD in Microbiology from The Ohio State University and subsequently completed two postdoctoral fellowships at MGH/Harvard Medical School: one in infectious diseases and another in biological chemistry and molecular pharmacology at the Harvard Institute of Proteomics.
In 2009, Dr. Rollins was appointed as a full-time instructor at Harvard Medical School, a position he held until 2012. He then joined Fitchburg State University as a tenure-track faculty member, where he achieved tenure and the rank of full professor.
Since 2007, Dr. Rollins has been part of the MCPHS community, bringing his expertise in infectious diseases to the classroom. He has taught a range of subjects, including microbiology, virology, parasitology, and general biology.
Education
- B.S. Rensselaer Polytechnic Institute, Troy, NY
- Ph.D., The Ohio State University, Columbus, OH
- Post-Doctoral Fellowship, Infectious Diseases, Harvard Medical School, Boston, MA
- Post-Doctoral Fellowship, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
Research Interests
- Researching host/pathogen interactions and gene regulation in Bacillus anthracis, Vibrio cholerae, and Salmonella species, with a focus on vaccine, diagnostic, and therapeutic development.
- Utilizing proteomic techniques to study immune responses during anthrax, cholera, and typhoid infections.
- Conducting gene expression analysis of a large family of Bacillus anthracis genes associated with transcriptional elements that suggest induced expression under specific amino acid limitations.
Featured Affiliations
American Society of Microbiology
WebsiteEducation
- B.S. Rensselaer Polytechnic Institute, Troy, NY
- Ph.D., The Ohio State University, Columbus, OH
- Post-Doctoral Fellowship, Infectious Diseases, Harvard Medical School, Boston, MA
- Post-Doctoral Fellowship, Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
Research Interests
- Researching host/pathogen interactions and gene regulation in Bacillus anthracis, Vibrio cholerae, and Salmonella species, with a focus on vaccine, diagnostic, and therapeutic development.
- Utilizing proteomic techniques to study immune responses during anthrax, cholera, and typhoid infections.
- Conducting gene expression analysis of a large family of Bacillus anthracis genes associated with transcriptional elements that suggest induced expression under specific amino acid limitations.
Publications
- Yersinia pestis and the plague. Rollins SE, Rollins SM, Ryan ET.Am J Clin Pathol. 2003 Jun;119 Suppl:S78-85. doi: 10.1309/DQM9-3R8Q-NQWB-FYU8.PMID: 12951845 Review.
- In vivo induced antigen technology (IVIAT). Rollins SM, Peppercorn A, Hang L, Hillman JD, Calderwood SB, Handfield M, Ryan ET.Cell Microbiol. 2005 Jan;7(1):1-9. doi: 10.1111/j.1462-5822.2004.00477.x.PMID: 15617518 Review.
- Crowd control: Bacillus anthracis and quorum sensing.Rollins SM, Schuch R.Virulence. 2010 Mar-Apr;1(2):57-9. doi: 10.4161/viru.1.2.11051.PMID: 21178417 Free article.
- Robust microarray production of freshly expressed proteins in a human milieu. Festa F, Rollins SM, Vattem K, Hathaway M, Lorenz P, Mendoza EA, Yu X, Qiu J, Kilmer G, Jensen P, Webb B, Ryan ET, LaBaer J.Proteomics Clin Appl. 2013 Jun;7(5-6):372-7. doi: 10.1002/prca.201200063. Epub 2013 May 17.PMID: 23027544 Free PMC article.
- Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A. Alam MM, Tsai LL, Rollins SM, Sheikh A, Khanam F, Bufano MK, Yu Y, Wu-Freeman Y, Kalsy A, Sultana T, Sayeed MA, Jahan N, LaRocque RC, Harris JB, Leung DT, Brooks WA, Calderwood SB, Charles RC, Qadri F, Ryan ET.Clin Vaccine Immunol. 2013 May;20(5):712-9. doi: 10.1128/CVI.00054-13. Epub 2013 Mar 13.PMID: 23486419 Free PMC article.
- Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. Charles RC, Harris JB, Chase MR, Lebrun LM, Sheikh A, LaRocque RC, Logvinenko T, Rollins SM, Tarique A, Hohmann EL, Rosenberg I, Krastins B, Sarracino DA, Qadri F, Calderwood SB, Ryan ET.PLoS One. 2009 Sep 10;4(9):e6994. doi: 10.1371/journal.pone.0006994.PMID: 19746165 Free PMC article.
- Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi. Harris JB, Baresch-Bernal A, Rollins SM, Alam A, LaRocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET.Infect Immun. 2006 Sep;74(9):5161-8. doi: 10.1128/IAI.00488-06.PMID: 16926408 Free PMC article.
- Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh. Sheikh A, Charles RC, Rollins SM, Harris JB, Bhuiyan MS, Khanam F, Bukka A, Kalsy A, Porwollik S, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET.PLoS Negl Trop Dis. 2010 Dec 7;4(12):e908. doi: 10.1371/journal.pntd.0000908.PMID: 21151879 Free PMC article.
- Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal. Charles RC, Sultana T, Alam MM, Yu Y, Wu-Freeman Y, Bufano MK, Rollins SM, Tsai L, Harris JB, LaRocque RC, Leung DT, Brooks WA, Nga TV, Dongol S, Basnyat B, Calderwood SB, Farrar J, Khanam F, Gunn JS, Qadri F, Baker S, Ryan ET.PLoS Negl Trop Dis. 2013 Aug 1;7(8):e2335. doi: 10.1371/journal.pntd.0002335. Print 2013.PMID: 23936575 Free PMC article.
- Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice. Tarique AA, Kalsy A, Arifuzzaman M, Rollins SM, Charles RC, Leung DT, Harris JB, Larocque RC, Sheikh A, Bhuiyan MS, Saksena R, Clements JD, Calderwood SB, Qadri F, Kovác P, Ryan ET.Clin Vaccine Immunol. 2012 Apr;19(4):594-602. doi: 10.1128/CVI.05689-11. Epub 2012 Feb 22.PMID: 22357651 Free PMC article.
- Interaction between the acceptor end of tRNA and the T box stimulates antitermination in the Bacillus subtilis tyrS gene: a new role for the discriminator base. Grundy FJ, Rollins SM, Henkin TM.J Bacteriol. 1994 Aug;176(15):4518-26. doi: 10.1128/jb.176.15.4518-4526.1994.PMID: 8045882 Free PMC article.
- Specificity of tRNA-mRNA interactions in Bacillus subtilis tyrS antitermination. Grundy FJ, Hodil SE, Rollins SM, Henkin TM.J Bacteriol. 1997 Apr;179(8):2587-94. doi: 10.1128/jb.179.8.2587-2594.1997.PMID: 9098057 Free PMC article.
- Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis. Rollins SM, Peppercorn A, Young JS, Drysdale M, Baresch A, Bikowski MV, Ashford DA, Quinn CP, Handfield M, Hillman JD, Lyons CR, Koehler TM, Calderwood SB, Ryan ET.PLoS One. 2008 Mar 19;3(3):e1824. doi: 10.1371/journal.pone.0001824.PMID: 18350160 Free PMC article.
- tRNA determinants for transcription antitermination of the Bacillus subtilis tyrS gene. Grundy FJ, Collins JA, Rollins SM, Henkin TM.RNA. 2000 Aug;6(8):1131-41. doi: 10.1017/s1355838200992100.PMID: 10943892 Free PMC article.
- Expression and secretion of transforming growth factor-beta by bleomycin-stimulated rat alveolar macrophages. Denholm EM, Rollins SM.Am J Physiol. 1993 Jan;264(1 Pt 1):L36-42. doi: 10.1152/ajplung.1993.264.1.L36.PMID: 7679254
- Analysis of cis-acting sequence and structural elements required for antitermination of the Bacillus subtilis tyrS gene. Rollins SM, Grundy FJ, Henkin TM.Mol Microbiol. 1997 Jul;25(2):411-21. doi: 10.1046/j.1365-2958.1997.4851839.x.PMID: 9282752 Free article.
- In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh. Sheikh A, Charles RC, Sharmeen N, Rollins SM, Harris JB, Bhuiyan MS, Arifuzzaman M, Khanam F, Bukka A, Kalsy A, Porwollik S, Leung DT, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET.PLoS Negl Trop Dis. 2011 Dec;5(12):e1419. doi: 10.1371/journal.pntd.0001419. Epub 2011 Dec 13.PMID: 22180799 Free PMC article.
- Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice. Ghose C, Kalsy A, Sheikh A, Rollenhagen J, John M, Young J, Rollins SM, Qadri F, Calderwood SB, Kelly CP, Ryan ET.Infect Immun. 2007 Jun;75(6):2826-32. doi: 10.1128/IAI.00127-07. Epub 2007 Mar 19.PMID: 17371854 Free PMC article. 22
- Induced Transcriptional Expression of Bacillus subtilis Amino Acid Permease yvbW in Response to Leucine Limitation. SM Rollins, Advances in Microbiology Vol.4 No.8, June 27, 2014 DOI: 10.4236/aim.2014.48053
- Alveolar macrophage secretion of a 92-kDa gelatinase in response to bleomycin. Denholm EM, Rollins SM.Am J Physiol. 1993 Dec;265(6 Pt 1):L581-5. doi: 10.1152/ajplung.1993.265.6.L581.PMID: 7506494
Awards and Honors
- Principle Investigator: Career Development Fellowship Award NIH funding through the New England Regional Center of Excellence in Biodefense and Emerging Infectious Diseases Analysis of Bacillus anthracis genes identified by IVIAT. 2004-2006 U54 AI057159