Kristina Holton
Adjunct Faculty
School
School of Healthcare Business and Technology
Department
School of Healthcare Business and Technology
About
Kristina Holton brings extensive experience bridging wet lab biology and bioinformatics, with a strong foundation in the biological principles underpinning statistical analyses. She has held roles at prestigious institutions, including the Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, the Perelman School of Medicine at the University of Pennsylvania, Harvard Medical School, WuXi NextCODE, Harvard University, and the Stanley Center of the Broad Institute of Harvard and MIT.
Her current research at Harvard and the Broad Institute focuses on single-cell genomics and leveraging machine learning and AI to study aging-related and musculoskeletal diseases.
Throughout her career, Kristina has demonstrated a deep commitment to education, serving as a mentor, teaching assistant, and instructor. At MCPHS, she strives to equip learners with robust data science fundamentals, preparing them to excel in their professional journeys.
Education
- Massachusetts Institute of Technology, SB Biology
- Brandeis University, MS Bioinformatics
- University of Delaware, PhD Bioinformatics
Research Interests
- Bioinformatics
- Biostatistics
- Machine Learning
- Applied AI
- Single Cell Genomics
Education
- Massachusetts Institute of Technology, SB Biology
- Brandeis University, MS Bioinformatics
- University of Delaware, PhD Bioinformatics
Research Interests
- Bioinformatics
- Biostatistics
- Machine Learning
- Applied AI
- Single Cell Genomics
Publications
- “Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration.” Price FD, Matyas MN, Gehrke AR, Chen W, Wolin EA, Holton KM, Gibbs RM, Lee A, Singu PS, Sakakeeny JS, Poteracki JM, Goune K, Pfeiffer IT, Boswell SA, Sorger PK, Srivastava M, Pfaff KL, Gussoni E, Buchanan SM, Rubin LL. Nat Biotechnol. 2024 Sep 11.
- “Heat shock protein 72 supports extracellular matrix production in metastatic mammary tumors.” Lang B.J., Holton K.M., Guerro-Gimenez M., Okusha Y. Magahis P. Shi A., Neguse M., Venkatesh S., Nhu A., Cszimadia E., Hunt C., Calderwood S.K. Cell Stress Chaperones 2024 Jun;29(3):456-471.
- “Alzheimer’s Disease: Models and Molecular Mechanisms Informing Disease and Treatments.” Nystuen, K.L.; McNamee, S.M.; Akula, M.; Holton, K.M.; DeAngelis, M.M.; Haider, N.B. Bioengineering 2024, 11, 45.
- “Activation of ER stress in ALS patient iPSC-derived motor neurons identifies druggable neuroprotective compounds.” Watts M. , Giadone R.M., Ordureau A., Holton K.M., Harper J.W., Rubin L.L.. Front Cell Neurosci. 2023; 17: 1327361.
- “A Workflow Guide to RNA-Seq Analysis of Chaperone Function and Beyond.” Holton K.M., Giadone R.M.. Lang B.J., Calderwood S.K. Methods Mol Biol. 2023;2693:39-60.
- “Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.” Ximerakis, M., Holton, K.M., Giadone, R.M. Ozek C., Saxena M., Santiago S., Adiconis X., Dionne D., Nguyen L., Shah K.M., Goldstein J.M., Gasperini C., Gampierakis I.A., Lipnick S.L., Simmons S.K., Buchanan S.M., Wagers A.J., Regev A., Levin J.Z., Rubin L.L. Nat Aging 3, 327–345 (2023).
- “A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.” Paul KC, Krolewski RC, Lucumi Moreno E, Blank J, Holton KM, Ahfeldt T, Furlong M, Yu Y, Cockburn M, Thompson LK, Kreymerman A, Ricci-Blair EM, Li YJ, Patel HB, Lee RT, Bronstein J, Rubin LL, Khurana V, Ritz B.Nat Commun. 2023 May 16;14(1):2803.
- “High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly.”Berryer MH, Rizki G, Nathanson A, Klein JA, Trendafilova D, Susco SG, Lam D, Messana A, Holton KM, Karhohs KW, Cimini BA, Pfaff K, Carpenter AE, Rubin LL, Barrett LE. Elife. 2023 Apr 21;12:e80168.
- “Exploring the influence of functional architecture on cortical thickness networks in early psychosis – a longitudinal study.” Holton K.M. Chan S.Y., Brockmeier A.J., Öngür D., Hall M.H. Neuroimage. 2023 Apr 20:120127.
- “Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.” Cell Stress Chaperones Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK.. 2022 Sep;27(5):461-478.
- “Mutations in PRDM15 Are a Novel Cause of Galloway-Mowat Syndrome.” Mann N, Mzoughi S, Schneider R, Kühl SJ, Schanze D, Klämbt V, Lovric S, Mao Y, Shi S, Tan W, Kühl M, Onuchic-Whitford AC, Treimer E, Kitzler TM, Kause F, Schumann S, Nakayama M, Buerger F, Shril S, van der Ven AT, Majmundar AJ, Holton KM, Kolb A, Braun DA, Rao J, Jobst-Schwan T, Mildenberger E, Lennert T, Kuechler A, Wieczorek D, Gross O, Ermisch-Omran B, Werberger A, Skalej M, Janecke AR, Soliman NA, Mane SM, Lifton RP, Kadlec J, Guccione E, Schmeisser MJ, Zenker M, Hildebrandt F. J Am Soc Nephrol. 2021 Mar;32(3):580-596.