Dan Kiel, PhD
Associate Professor of Pharmacology
School
School of Pharmacy
Department
Pharmaceutical Sciences
Office Location
White 317
Boston
Office Phone Office Phone: 617.732.2975
About
Dr. Kiel is a pioneering pharmacologist known for his discovery and characterization of ago-allosteric modulators—compounds that enhance the effects of endogenous ligands while independently activating receptors. His groundbreaking research identified the first such compounds targeting the human GLP-1 receptor, contributing to the development of orally available medications for this receptor.
In collaboration with students, Dr. Kiel conducted studies demonstrating the potential of GLP-1 to improve neural deficits in rat models of peripheral neuropathy. His research also explored biased signaling in commercially available GLP-1 agonists, advancing understanding of their therapeutic potential.
An esteemed educator, Dr. Kiel has been recognized as Teacher of the Year five times by his department, a distinction awarded by students for his outstanding teaching and mentorship.
Education
- BS, Massachusetts College of Pharmacy, 1984
- MS, Northeastern University, Pharmacology, 1987
- MBA, University of San Diego, 1999
- PhD, Columbia University, Pharmacology, 1993.
Research Interests
- Modulation of G protein-coupled receptors
- Incretin peptides
- Drug discovery and development
Featured Affiliations
American Society for Pharmacology and Experimental Therapeutics
WebsiteEducation
- BS, Massachusetts College of Pharmacy, 1984
- MS, Northeastern University, Pharmacology, 1987
- MBA, University of San Diego, 1999
- PhD, Columbia University, Pharmacology, 1993.
Research Interests
- Modulation of G protein-coupled receptors
- Incretin peptides
- Drug discovery and development
Awards and Honors
- Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J. Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor. Bioorganic & Medicinal Chemistry Letters 2007 Oct 1; 17 (19):5472-8.
- Lotte Bjerre Knudsen, Dan Kiel, Min Teng, Carsten Behrens, Dilip Bhumralkar, János T. Kodra, Jens J. Holst, Claus B. Jeppesen, Michael D. Johnson, Johannes Cornelis de Jong, Anker Steen Jorgensen, Tim Kercher, Jarek Kostrowicki, Peter Madsen, Preben H. Olesen, Jacob S. Petersen, Fritz Poulsen, Ulla G. Sidelmann, Jeppe Sturis, Larry Truesdale, John May, and Jesper Lau: Small-molecule agonists for the glucagon-like peptide 1 receptor. PNAS 104: 937-942, 2007.
- Lau J, Behrens C, Sidelmann UG, Knudsen LB, Lundt B, Sams C, Ynddal L, Brand CL, Pridal L, Ling A, Kiel D, Plewe M, Shi S, Madsen P.: New beta-alanine derivatives are orally available glucagon receptor antagonists. Journal of Medicinal Chemistry 50 (1): 113 - 128, 2007.
- Peter Madsen, Anthony Ling, Michael Plewe, Christian K. Sams, Lotte B. Knudsen, Ulla G. Sidelmann, Lars Ynddal, Christian L. Brand, Birgitte Andersen, Douglas Murphy, Min Teng, Larry Truesdale, Dan Kiel, John May, Atsuo Kuki, Shenghua Shi, Michael D. Johnson, Kimberly Ann Teston, Jun Feng, James Lakis, Kenna Anderes, Vlad Gregor, and Jesper Lau: Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide. Journal of Medicinal Chemistry 45: 5755 - 5775, 2002.
- Anthony Ling, Michael Plewe, Javier Gonzalez, Peter Madsen, Christian K. Sams, Jesper Lau, Vlad Gregor, Doug Murphy, Kimberly Teston, Atsuo Kuki, Shenghua Shi, Larry Truesdale, Dan Kiel, John May, James Lakis, Kenna Anderes, Eugenia Iatsimirskaia, Ulla G. Sidelmann, Lotte B. Knudsen, Christian L. Brand and Alex Polinsky: Human Glucagon Receptor Antagonists Based on Alkylidene Hydrazides. Bioorganic & Medicinal Chemistry Letters 12: 663 - 666, 2002.
- Anthony Ling, Yufeng Hong, Javier Gonzalez, Vlad Gregor, Alex Polinsky, Atsuo Kuki, Shenghua Shi, Kimberly Teston, Douglas Murphy, John Porter, Dan Kiel, James Lakis, Kenna Anderes, John May, Lotte Bjerre Knudsen and Jesper Lau: Identification of Alkylidene Hydrazides as Glucagon Receptor Antagonists. Journal of Medicinal Chemistry 44: 3141 - 3149, 2001.
- Kiel D, Feinmark SJ: Phospholipase D Activity Regulates the Binding of Leukotriene B4 to Human Polymorphonuclear Leukocytes. Journal of Pharmacology and Experimental Therapeutics 278: 645 - 653, 1996.
- Hughes RJ, Anderson KL, Kiel D, Insel PA: Cloning of GRK2 cDNA from S49 murine lymphoma cells. American Journal of Physiology 270: C885 - C891, 1996.
- Ping P, Gelzer-Bell R, Roth DA, Kiel D, Insel PA, Hammond HK: Reduced Beta-Adrenergic Receptor Activation Decreases G-Protein Expression and Beta-Adrenergic Receptor Kinase Activity in Porcine Heart. Journal of Clinical Investigation 95: 1271 - 1280, 1995.
- Kiel D, Zipkin RE, Feinmark SJ: Desensitization of the Leukotriene B4 Receptor by Partial Agonists. Advances in Prostaglandin, Thromboxane and Leukotriene Research 21: 403 - 406, 1990.