Saravanan Subramaniam, Ph.D.
Assistant Professor of Pharmacology & Toxicology
School
School of Pharmacy
Department
Pharmaceutical Sciences
Office Location
White 330
Boston
Office Phone Office Phone: 617.732.2201
About
Dr. Saravanan Subramaniam focuses his research on understanding the pathophysiological mechanisms of infection-induced inflammation and coagulation. His work aims to identify pharmacological targets through intervention studies to mitigate complications such as thrombosis and organ failure resulting from infections.
For the past nine years, Dr. Subramaniam has utilized advanced imaging techniques and preclinical humanized mouse models to investigate blood cell-vessel wall interactions and fibrin generation. His research has significantly contributed to understanding the development of venous thrombi and potential therapeutic strategies to address these challenges.
Education
- Doctorate in Medicine, Justus Liebig University
- Master in Pharmacology, SASTRA University
- Bachelor in Pharmacy, Dr. MGR Medical University
Additional Trainings
- CTSI career developmental grant writing workshop 2022, Boston University, USA
- New England future faculty workshop 2021, Northeastern University, USA
- Federation for Laboratory Animal Science Associations (FELASA-C, EMBL, ITALY
- Quantitative methods in clinical & public health research, Harvard University, USA
- Federation for Laboratory Animal Science Associations (FELASA)-B, BERLIN
- Certificate course on Drug Design and Molecular Modeling, SASTRA University, INDIA
- Safety aspects in the research applications of ionization radiation, BARC, INDIA
- Basic electronics & computer applications, INDIA
Research Interests
- Sepsis
- Thrombosis
- Thrombo-inflammatory responses
Education
- Doctorate in Medicine, Justus Liebig University
- Master in Pharmacology, SASTRA University
- Bachelor in Pharmacy, Dr. MGR Medical University
Additional Trainings
- CTSI career developmental grant writing workshop 2022, Boston University, USA
- New England future faculty workshop 2021, Northeastern University, USA
- Federation for Laboratory Animal Science Associations (FELASA-C, EMBL, ITALY
- Quantitative methods in clinical & public health research, Harvard University, USA
- Federation for Laboratory Animal Science Associations (FELASA)-B, BERLIN
- Certificate course on Drug Design and Molecular Modeling, SASTRA University, INDIA
- Safety aspects in the research applications of ionization radiation, BARC, INDIA
- Basic electronics & computer applications, INDIA
Research Interests
- Sepsis
- Thrombosis
- Thrombo-inflammatory responses
Publications
Original, Peer Reviewed Articles (*)
- Saravanan Subramaniam, Naila Mohiuddin, Asha Jose. Does SARS-CoV-2 infect platelets? – Frontiers in Immunology, 23 April 2024 - Corresponding author [IF:7.5] (*).
- Dennis R Riehl, Arjun Sharma, Julian Roewe, Florian Murke, Clemens Ruppert, Sabine A Eming, Tobias Bopp, Hartmut Kleinert, Markus P Radsak, Giuseppe Colucci, Saravanan Subramaniam, Christoph Reinhardt, Bernd Giebel, Immo Prinz, Andreas Guenther, Dennis Strand, Matthias Gunzer, Ari Waisman, Peter A Ward, Wolfram Ruf, Katrin Schäfer, and Markus Bosmann. Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27. Proc Natl Acad Sci USA (PNAS). 2023 Oct 3;120(40):e2215421120. [IF:11.1] (*).
- Palanisamy Kannan, Peng Wang, Lu Lei, Hui Wang, Saravanan Subramaniam, and Shan Ji. Fe-FeNn nanoparticles anchored bamboo-like morphology of N‑doped graphitic carbon nitride nanotubes enabled electrochemical DNA-based biosensing of head and neck-squamous cell carcinoma miRNA-203. Accepted (August 18, 2023) in Applied Physics Letters – Corresponding author [IF:4] (*).
- Siang Zhou, Palanisamy Kannan, Bharathi Natarajan, Saravanan Subramaniam. Recent progress in optical and electrochemical methods-based prolactin immunobiosensors – Microchemical Journal- Accepted July 15, 2023- Corresponding author [IF:4.5] (*).
- Saravanan Subramaniam, Christoph Reinhardt, Paresh Kulkarni, and Luca Spiezia. Editorial: COVID-19 and thrombo-inflammatory responses – Front. Cardiovasc. Med., 15 June 2023 - Corresponding author [IF:5.5] (*).
- Saravanan Subramaniam, Hema Kothari, and Markus Bosmann. Tissue factor in COVID-19 associated coagulopathy. Thromb Res. 2022 Dec;220:35-47 - Corresponding author [IF:10.4] (*).
- Saravanan Subramaniam, Ryan Matthew Hekman, Archana Jayaraman, Aoife Kateri O’Connell, Paige Montanaro, Benjamin Blum, Devin Kenney, Maria Ericsson, Katya Ravid, Nicholas A Crossland, Andrew Emili, Florian Douam, Markus Bosmann. Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice. BioRxiv 2023, doi: 10.1101/2021.08.19.457020 [Preprint].
- Saravanan Subramaniam, Jiandong LU, Craig Fletcher, Ramani Ramchandran and Hartmut Weiler. Coagulation Factor IIIa (f3a) Knockdown in Zebrafish Leads to Defective Angiogenesis and Mild Bleeding Phenotype. Front Cell Dev Biol. 2022 Mar 21;10:852989- Corresponding author [IF:6.6] (*).
- Mariano Carossino, Paige Montanaro, Aoife O'Connell, Devin Kenney, Hans Gertje, Kyle Grosz, Maria Ericsson, Bertrand R Huber, Saravanan Subramaniam, Thomas A Kirkland, Joel R Walker, Kevin P Francis, Alexander D Klose, Neal Paragas, Susanna Kurnick, Markus Bosmann, Mohsan Saeed, Udeni Balasuriya, Florian Douam, and Nicholas Crossland. Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression. Viruses. 2022 Mar 5;14(3):535 - [IF:5.05] (*).
- Saravanan Subramaniam, Wolfram Ruf, and Markus Bosmann. Advocacy of Targeting Protease-Activated Receptors in Severe COVID-19. Br J Pharmacol. 2021 Jul 7. doi: 10.1111/bph.15587. Online ahead of print. PMID: 34235728. - Corresponding author [IF:8.7] (*).
- Nathan Eaton, Saravanan Subramaniam, Marie L. Schulte, Caleb Drew, David Jakab, Sandra L. Haberichter, Hartmut Weiler, and Hervé Falet. Bleeding diathesis in mice lacking JAK2 in platelets – Accepted, April 15, 2021– Blood Adv. 2021 Aug 10;5(15):2969-2981. [IF:6.7] (*).
- Saravanan Subramaniam, Yamini Ogoti1, Irene Hernandez, Mark Zogg, Fady Botros, Robert Burns, Jacob T. DeRousse, Chris Dockendorff, Nigel Mackman, Silvio Antoniak, Craig Fletcher, and Hartmut Weiler. A thrombin-PAR1/2 feedback loop amplifies thrombo-inflammatory endothelial responses to the viral RNA analogue poly(I:C) – Blood Adv. 2021 Jul 13;5(13):2760-2774. PMID: 34242391. [IF:6.7] (*).
- Chunyan Gao, Jocelyn A. Schroeder, Feng Xue, Weiqing Jing, Yuanhua Cai, Amelia Scheck, Saravanan Subramaniam, Sridhar Rao, Hartmut Weiler, Agnieszka Czechowicz, and Qizhen Shi. Non-genotoxic antibody-drug-conjugate conditioning enables safe and effective platelet gene therapy of hemophilia A mice – Blood Adv. 2019 Sep 24;3(18):2700-2711. PMID: 31515232. [IF:6.7] (*).
- Saravanan Subramaniam, Boukhlouf S, and Craig Fletcher. A bacterial metabolite, Trimethylamine N-oxide (TMAO), disrupts the hemostasis balance in human primary endothelial cells but no coagulopathy in mice - Blood Coagul. Fibrinolysis. 2019 Oct;30(7):324-330. PMID: 31490208 - Corresponding author [IF:1.3] (*).
- Klytaimnistra Kiouptsi, Sven Jäckel, Giulia Pontarollo, Alexandra Grill, Marijke J. E. Kuijpers, Eivor Wilms, Christian Weber, Felix Sommer, Magdolna Nagy, Carlos Neideck, Yvonne Jansen, Stefanie Ascher, Henning Formes, Cornelia Karwot, Franziska Bayer, Bettina Kollar, Saravanan Subramaniam, Michael Molitor, Philip Wenzel, Philip Rosenstiel, Hristo Todorov, Susanne Gerber, Ulrich Walter, Kerstin Jurk, Johan W. M. Heemskerk, Emiel P. C. van der Vorst, Yvonne Döring, and Christoph Reinhardt. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio. 2019 Sep-Oct; 10(5): e02298-19. PMID: 31641089. [IF:7.9] (*).
- Mark W Majewski, Disha M Gandhi, Trudy Holyst, Zhengli Wang, Irene Hernandez, Ricardo Rosas Jr, Saravanan Subramaniam, Jieqing Zhu, Hartmut Weiler, Chris Dockendorff. Synthesis and Initial Pharmacology of Heterobivalent Ligands Targeting Putative Complexes of Integrin αVβ3 and PAR2. ChemRxiv.2019; doi.org/10.26434/chemrxiv.9771014.v2.
- Disha M. Gandhi, Ricardo Rosas, Jr., Eric Greve, Kaitlin M. Kentala, N'Guessan D.-R. Diby, Vladyslava A. Snyder, Allison Stephans, Teresa H. Y. Yeung, Saravanan Subramaniam, Khia E. Kurtenbach, Elliot DiMilo, Leggy A. Arnold, Hartmut Weiler and Chris Dockendorff. The Parmodulin NRD21 is an Allosteric Inhibitor of PAR1 Gq Signaling with Improved Anti-Inflammatory Activity and Stability. Bioorg. Med. Chem. 2019 Sep 1;27(17):3788-3796. PMID: 31320211. [IF:3.6] (*).
- Michael Etscheid, Saravanan Subramaniam, Günther Lochnit, Michal Zabczyk, Anetta Undas, Irene M. Lang, Kai-Martin Hanschmann, Sandip M. Kanse. Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP) –Biochim. Biophys. Acta. Mol. Basis. Dis. 2018 Oct;1864(10):3397-3406. PMID: 30076961. [IF:5.2] (*).
- Michael F Bode, Alyson C Auriemma, Steven Grover, Yohei Hisada, Alex Rennie, Weeranun D Bode, Rashi Vora, Saravanan Subramaniam, Brian Cooley, Patricia Andrade-Gordon, Silvio Antoniak, Nigel Mackman. The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction. Thromb. Res. 2018 May 17;167:128-134. PMID: 29843086. [IF:4.0] (*).
- Saravanan Subramaniam and Inge Scharrer. Procoagulant activity during viral infections. Front Bioscience (Landmark Ed). 2018 Jan 1;23:1060-1081. PMID: 28930589 - Invited Review [IF:3.89] (*).
- Saravanan Subramaniam and Craig Fletcher. Trimethylamine N‐oxide: breathe new life. British Journal of Pharmacology. 2018 Apr;175(8):1344-1353. PMID: 28745401.- Corresponding author [IF:8.7] (*).
- Saravanan Subramaniam, Trimethylamine oxide (TMAO): a new toxic kid on the block. Journal of Biomolecular Research & Therapeutics, vol. 7, no. 1, 2018. doi:10.4172/2167-7956.1000e159 – Editorial (*)
- Saravanan Subramaniam, Sandip M. Kanse, Hema Kothari, Christoph Reinhardt and Craig Fletcher. Post-transcriptional, -translational and pharmacological regulation of Tissue Factor Pathway Inhibitor (TFPI) – Blood Coagulation and Fibrinolysis. 2018 Dec;29(8):668-682. PMID: 30439766 - Corresponding author [IF:1.3] (*).
- Sven Jäckel, Maren Lillich, Klytaimnistra Kiouptsi, Nives Hörmann, Avinash Khandagale, Cora Reiss, Saravanan Subramaniam, Katharina Alber, Sabine Kossmann, Philip Wenzel, Kerstin Jurk, Marie-Luise von Brühl, Zaverio Ruggeri, Steffen Massberg, Ulrich Walter, Wolfram Ruf and Christoph Reinhardt. Gut microbiota regulates hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood. 2017, Jul 27;130(4):542-553. PMID: 28572286. [IF:23.63] (*).
- Clara Jana-Lui Busch, Tim Hendrikx, David Weismann, Sven Jäckel, Sofie M. A. Walenbergh, André F. Rendeiro, Anastasiya Hladik, Laura Göderle, Gerald Haas, Vincent Millischer, Saravanan Subramaniam, Sylvia Knapp, Christoph Bock, Christoph Reinhardt, Ronit Shiri-Sverdlov, Christoph J. Binder. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice –Hepatology. 2017 Apr;65(4):1181-1195. PMID: 27981604. [IF:17.43] (*).
- Saravanan Subramaniam, Kerstin Jurk, Lukas Hobohm, Sven Jäckel, Mona Saffarzadeh, Kathrin Schwierczek, Philip Wenzel, Florian Langer, Christoph Reinhardt and Wolfram Ruf.Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development – Blood. 2017 Apr 20;129(16):2291-2302. PMID: 28223279. [IF: 23.63] (*).
- Joerg Herold, Steven Nowak, Sawa Kostin, Jan-Marcus Daniel, Alexander Francke, Saravanan Subramaniam, Ruediger. C. Braun-Dullaeus, Sandip M. Kanse. Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model – Am J Transl Res. 2017 Jun 15;9(6):3084-3095. PMID: 28670395. [IF:4.06] (*).
- Klytaimnistra Kiouptsi, Alexandra Grill, Amrit Mann, Mareike Döhrmann, Maren Lillich, Sven Jäckel, Frano Malinarich, Henning Formes, Davit Manukyan, Saravanan Subramaniam, Avinash Khandagale, Cornelia Karwot, Serge C. Thal, Markus Bosmann, Inge Scharrer, Kerstin Jurk, and Christoph Reinhardt. Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PLoS One. 2017 Aug 24;12(8):e0183590. PMID: 28837614. [IF:3.20] (*).
- Natascha Luther, Melanie Brähler, Franziska Krebs, Sven Jäckel, Saravanan Subramaniam, Christian Stanger, Tanja Schönfelder, Christoph Reinhardt, Philip Wenzel, Katrin Schäfer and Christian Becker. Innate effector-memory T cell activation regulates post-thrombotic vein wall inflammation and thrombus resolution- Circulation Research. 2016 Dec 9;119(12):1286-1295. PMID: 27707800. [IF:17.36] (*).
- Kohei Tatsumi, Silvio Antoniak, Saravanan Subramaniam, Bertrand Gondouin, Scott D. Neidich, Melinda A. Beck, Jacqueline Mickelson, Dougald M. Monroe III, Julie A. Bastarache and Nigel Mackman. Anticoagulation Increases Alveolar Hemorrhage in Mice Infected with Influenza A – Physiol Rep. 4 (24), 2016, e13071. PMID: 28003564. [IF:1.88] (*).
- Saravanan Subramaniam, Thielmann I, Etscheid M, Morowski M, Pragst I, Nieswandt B, Kanse, S M. efective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP) – Thromb. Haemost. 2015 Apr;113(4):870-80. PMID: 25427855. [IF:5.24] (*).
- Saravanan Subramaniam and Sandip Kanse. Ferric chloride (FeCl3) - induced carotid arterial thrombosis in mice – Current Protocols in Mouse Biology.2014, 4:151–164. PMID: 25723183 - Corresponding author (*)
- Saravanan Subramaniam, Ramachandran Subramaniam, Suja Rajapandian, Subasini Uthrapathi and Victor Rajamanickam G. Anti-Atherogenic activity of ethanolic fraction of Terminalia arjuna bark on hypercholesterolemic Rabbits – Evidence Based Complementary and Alternative Medicine. doi:10.1093/ecam/neq003, January 2011. PMID: 21785628. - Corresponding author [IF:2.40] (*).
- Saravanan Subramaniam, Ramachandran Subramaniam, Subasini Utherapathy, Rajamanickam G Victor. Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX-407 induced hyperlipidemia – Indian Journal of Experimental Biology. April 2011. PMID: 21614892. Corresponding author [IF:1.2] (*).
- Ramachandran Subramaniam, Asokkumar Kuppusamy, Uma Maheswari Muthusamy, Ravi T Kochupapy, Sivashanmugam A Thirumalaisamy, Saravanan Subramaniam, Rajasekaran Aiyalu, and Dharman Jogi. Investigation of Antidiabetic, Antihyperlipidemic and in vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 diabetic rats: An Identification of Possible Biomarkers. (Evidence Based Complementary and Alternative Medicine, August, 2011). PMID: 20953435. [IF:2.40] (*).
- Kalaivani Anbarasan, Niranjan.Vishnu, Hemavathi kathiresan, Nitin kumar, Saravanan Subramaniam, and Ponmari Rajan. Comprehensive Analysis of Mesothelin Gene in Asbestos Related Human Mesothelioma. Journal of Theoretical and Applied Information Technology, April 2008; 4:4. (*)
- Pulok K Mukherjee, Saravanan Subramaniam, Nema NK. Herbs from the Himalayas enumeration of the ethnomedicinal plants – Journal of Hill Research, 32:2, 272-276, 2009. (*)
- Manivel Kannan, Saravanan Subramaniam, Savariraj Sagayam, Jipnomonen Joseph, Muthusami Karthikeyan. Toxicological Evaluation of Methanolic Extract of Salacia chinensis Roots in Wistar Albino Rats - International Journal of Universal Pharmacy and Life Sciences 1(3): 145-155, 2011(*).
Book Chapters
- Ramanathan, V. Muthuswamy, S. Saravanan and A.K. Chandrasekharn Turmeric an Indian curry- It’s phytochemical and pharmacological prospective with special reference to anti-inflammatory action recent progress in medicinal plants. Vol. 17: Phytochemistry and Pharmacology III, Eds. V.K. SINGH, J.N. GOVIL & C. ARUNACHALAM Year: 2007, ISBN: 1- 9336990-7- 8 (*).
Awards & Honors
- 2024 Early career award, ISTH-2024, Bangkok, THAILAND
- 2023 Early career award, ISTH-2023, Montreal, CANADA
- 2023 Travel award, Hemostasis and Thrombosis Research Society (HTRS) meeting, Orlando, USA
- 2022 Early career award, ISTH-2022, London, UNITED KINGDOM
- 2022 Best research poster award-10th symposium on Hemostasis, UNC-Chapel Hill, USA
- 2021 Early career award, ISTH-2021, USA
- 2021 Travel award, Hemostasis and Thrombosis Research Society (HTRS) meeting, San Diego, USA
- 2020 CTSI-Fellowship-manuscript writing intensive, Medical College of Wisconsin, USA
- 2019 Early career award, ISTH-2019, AUSTRALIA
- 2019 Travel grant, National postdoc association (NPA), USA
- 2019 MCW-BRI postdoctoral travel award-Spring 2019, USA
- 2018 Young investigator award, CSATVB-2018, Toronto, CANADA
- 2018 Best research poster award-9th symposium on Hemostasis, UNC-Chapel Hill, USA
- 2017 Young investigator award, ISTH-2017, GERMANY
- 2015 BMBF-CTH training fellowship 2015: EMBL-FELASA C, Monterotondo, ITALY
- 2015 DAAD-Travel grant, ISTH-2015, CANADA
- 2015 BMBF-CTH training fellowship 2015: visit to university of Vienna, AUSTRIA
- 2015 Young investigator award, ISTH-2015, CANADA
- 2014 STEBT-Lectureship, German Academic Exchange Service, Justus Liebig University, GERMANY
- 2013 GlaxoSmithKline (GSK) - Travel grant (ISTH 2013, THE NETHERLANDS)
- 2013 STEBT-Lectureship, German Academic Exchange Service, Justus Liebig University, GERMANY
- 2012 DAAD-Research Exchange Grant, Prof. Biessen Lab, Maastricht University, THE NETHERLANDS
- 2012 STEBT-Lectureship, German Academic Exchange Service, Justus Liebig University, GERMANY
- 2009 Best oral presentation award, SRM University, INDIA
- 2008 University rank holder, Department of Pharmacology, SASTRA University, INDIA
- 2004 Best research poster award, PSG College of Pharmacy, INDIA
- 2003 Humanitarian service award, PSG College of Pharmacy, INDIA
Memberships & Affiliations
- 2023- Present Member of American Association of colleges of Pharmacy (AACP), USA
- 2020 – 2024 Member, Affinity Research Collaborative ‘Respiratory Viruses: A Focus on COVID-19’, Boston University
- 2020- Present Member, Affinity Research Collaborative ‘Thrombosis and Hemostasis’, Boston University
- 2019 – Present Member of British Pharmacological Society
- 2016 – 2018 Member, American Heart Association (AHA)
- 2015 – 2020 Member, Royal Society of Chemistry (MRSC)
- 2014 – Present Member, Scandinavian Society for Atherosclerosis Research (SSAR)
- 2013 – Present Member, International Society on Thrombosis and Haemostasis (ISTH)
- 2005 – Present Pharmacist Pharmacy Council of India (PCI)