Tewodros Eguale

Tewodros Eguale, MD, MS, PhD

Professor of Epidemiology and Biostatistics

he/him

School

School of Pharmacy

Department

School of Pharmacy

Office Location

Matricaria 4006G

Boston

About

Dr. Eguale’s has seven years of clinical practice experience along with an M.Sc. degree (genetic epidemiology of tuberculosis), and a PhD (Novel use of EHRs to estimate the prevalence of off- label prescribing, determinants and its association with adverse drug events). His research includes comparative safety and effectiveness of drugs, pharmacosurveillance, measuring conservative prescribing practices, and medication adherence. His work has contributed significantly to priority areas identified by the WHO to incorporate active surveillance to drug monitoring. Dr. Eguale has done extensive research on off-label prescribing practices and physicians’ determinants of off-label prescribing. His research was the first to link off-label use to adverse drug events in adult population. Dr. Equale has done additional work that evaluated information technologies to improve medication safety using EHRs. His PhD and M.Sc. graduates are working in pharmaceutical industries (e.g. Merck), consulting firms, and universities.

Education

  • M.D., M.Sc., PhD

Research Interests

  • Clinician-Based Validation of MedAware System to Identify Patients at Risk of Opioid Use Disorder
  • Evaluation of Personal Formularies of Primary Care Physicians Across Health Care Systems
  • Comparative safety and effectiveness of antipsychotics for the treatment of dementia
  • Comparative safety and effectiveness of amitriptyline (off-label) and other FDA approved drugs for fibromyalgia
  • Cost-effectiveness analysis of drugs and surgical treatments.
  • Measuring prevalence of off-label prescribing and identification of determinants of off-label prescribing.
  • Development of an adverse drug event evaluation software
  • Development, implementation and validation of new features in EHRs e.g. capturing reasons for drug discontinuations
  • Evaluation of appropriateness of medication alert overrides and identification of determinants of medication alert overrides.
  • Measurement of primary non-adherence, and elucidation of determinants including cost of medications, continuity of care and co-pays and deductibles
  • Validation of data documentation of treatment indications and treatment outcomes using electronic health records.

Featured Affiliations

International Society for Pharmacoepidemiology (ISPE)

Website

International Society for Pharmacoeconomics and Outcome Research (ISPOR)

Website

American Medical Informatics Association (AMIA)

Website

American Association of Colleges of Pharmacy (AACP)

Website

Education

  • M.D., M.Sc., PhD

Research Interests

  • Clinician-Based Validation of MedAware System to Identify Patients at Risk of Opioid Use Disorder
  • Evaluation of Personal Formularies of Primary Care Physicians Across Health Care Systems
  • Comparative safety and effectiveness of antipsychotics for the treatment of dementia
  • Comparative safety and effectiveness of amitriptyline (off-label) and other FDA approved drugs for fibromyalgia
  • Cost-effectiveness analysis of drugs and surgical treatments.
  • Measuring prevalence of off-label prescribing and identification of determinants of off-label prescribing.
  • Development of an adverse drug event evaluation software
  • Development, implementation and validation of new features in EHRs e.g. capturing reasons for drug discontinuations
  • Evaluation of appropriateness of medication alert overrides and identification of determinants of medication alert overrides.
  • Measurement of primary non-adherence, and elucidation of determinants including cost of medications, continuity of care and co-pays and deductibles
  • Validation of data documentation of treatment indications and treatment outcomes using electronic health records.

Publications

Awards and Honors